PDF BookExcitation-Contraction Coupling and Cardiac Contractile Force (Developments in Cardiovascular Medicine)

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Book Details :
Published on: 2001-08-01
Released on: 2001-08-31
Original language: English

How is the heartbeat generated What controls the strength of contraction of heart muscle What are the links between cardiac structure and function How does our understanding of skeletal and smooth muscle and non-muscle cells influence our thinking about force development in the heart Are there important species differences in how contraction is regulated in the heart How do the new molecular data fit together in understanding the heart beat What goes wrong in ischemia, hypertrophy, and heart failure This book paints a modern `portrait' of how the heart works and in this picture the author shows a close-up of the structural, biochemical, and physiological links between excitation and contraction. The author takes the reader through a series of important, interrelated topics with great clarity and continuity and also includes many useful illustrations and tables. The book starts by considering the cellular structures involved in excitation-contraction coupling and then described the characteristics of the myofilaments as the end effector of excitation-contraction coupling. A general scheme of calcium regulation is described and the possible sources and sinks of calcium are discussed in simple, but quantitative terms. The cardiac action potential and its many underlying currents are reviewed. Then the characteristics of some key calcium transport systems (calcium channels, sodium/calcium exchange and SR calcium uptake and release) are discussed in detail. This is then built into a more integrated picture of calcium regulation in succeeding chapters by detailed discussions of excitation-calcium coupling mechanisms (in skeletal, cardiac, and smooth muscle), the interplay between calcium regulatory processes, and finally mechanisms of cardiac inotropy, calcium overload, and dysfunction (e.g., ischemia, hypertrophy, and heart failure). Excitation-Contraction Coupling and Cardiac Contractile Force endash; Second Edition is an invaluable source of information for anyone who is interested in how the heart beat is controlled and especially suited for students of the cardiovascular system at all levels from medical/graduate students through senior investigators in related fields. Dissertationen-Datenbank - Medizinstudium Bern 9.12.2009 Dr. med. zlem zdemir (Bern / BE) unter der Leitung von Prof. Dr. R.R. Friis Epithelial Mesenchymal Transition as a Phenotype of Mammary Epithelial ... Grip Strength Meter - colinst.com Mouse Grip Strength Meters 1027SM Grip Strength Meter with Single Sensor for Mice with Standard Pull Bars and Software 1027DM Grip Strength Meter with Dual Sensors ... The Effect of Digoxin on Mortality and Morbidity in ... Original Article. The Effect of Digoxin on Mortality and Morbidity in Patients with Heart Failure. The Digitalis Investigation Group * N Engl J Med 1997; 336:525-533 ... The Sympathetic Nervous System in Heart Failure ... The sympathetic outflow to the heart and peripheral circulation is regulated by cardiovascular reflexes. Afferent fibers are usually carried toward the central ... Advanced Search Circulation Home; About this Journal. Editorial Board; General Statistics; Circulation Cover Doodle Blip the Doodle; Go Red For Women's Issue; Information for Advertisers Course Descriptions Advanced Academic Programs Johns ... This course covers cell organization and subcellular structure. Students examine the evolution of the cell chromosome and plasma membrane structures and behaviors ... CPB 0140 - Genetic Testing - Aetna Number: 0140. Policy. Aetna considers genetic testing medically necessary to establish a molecular diagnosis of an inheritable disease when all of the following are met:
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